… The interaction between tizanidine and CYP1A2 inhibitors has … Studies have also shown
that furafylline reduces caffeine … and explored the inhibitory effect of rofecoxib on CYP1A2. The …

… Tizanidine is more sensitive than caffeine and theophylline as a probe substrate for … time
profile for tizanidine (upper panel) and rofecoxib (lower panel) in healthy volunteers. Included in …

… So far, only one study from our group is available that … , ethinyl estradiol, and rofecoxib. Their
combination with … 5–15 days reduced serum AUC of caffeine and tizanidine by 50–60% [64,…

… Tizanidine is primarily metabolized via cytochrome P450 (… to CYP1A2 inhibitors, illicit drugs,
cigarette smoke, and coffee, … terms, and this study showed that rofecoxib was associated with …

… a time-dependent inhibition of cytochrome P450 1A2 (CYP1A2). • … dose of caffeine used in
this study is considered safe and it is … [27] estimated rofecoxib’s effect on theophylline (another …

… of tizanidine with a potent inhibitor of the cytochrome P-450 1A2 (CYP1A2) enzyme can …
Both of the studied cohorts were mainly healthy patients as over half of them had an Elixhauser …

… by CYP1A2 in manners similar to tizanidine, for example. Schulz, … is a powerful demethylase
for caffeine, and in humans, … CYP targets of the inhibitors studied during this research. Bold …

… , it was observed that the subjects in this study were associated with … ) Rofecoxib is a potent
inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. Br …

… Several cytochrome P450 (CYP) isoforms are implicated in caffeine … 74 patients with
Alzheimer’s disease and 72 healthy subjects … This study showed that caffeine intake was inversely …

… drugs, namely, caffeine and tacrine. In conclusion, pinocembrin has a … Rofecoxib
increased the plasma concentration of the CYP1A2 substrate tizanidine by 13.6-fold in humans…